Notes
The global cortical atrophy scale
- In the original study axial T2-weighted sequences were used for assessment
- Each region is assigned a score of 0-3 by visual rating:
- 0 – normal volume / no ventricular enlargement
- 1 – opening of sulci / mild ventricular enlargement
- 2 – volume loss of gyri / moderate ventricular enlargement
- 3 – severe (“knife blade”) atrophy / severe ventricular enlargement
- The range of the score is thus 0-39
- Intraobserver variability of the global cortical atrophy scale was found to be good, while interobserver variability is moderate to poor
- Pasquier F, Leys D, Weerts JG, Mounier-Vehier F, Barkhof F, Scheltens P. Inter- and intraobserver reproducibility of cerebral atrophy assessment on MRI scans with hemispheric infarcts. Eur Neurol. 1996;36(5):268-72. doi: 10.1159/000117270. PMID: 8864706.
- Scheltens P, Pasquier F, Weerts JG, Barkhof F, Leys D. Qualitative assessment of cerebral atrophy on MRI: inter- and intra-observer reproducibility in dementia and normal aging. Eur Neurol. 1997;37(2):95-9. doi: 10.1159/000117417. PMID: 9058064.
Further reading
Last updated: 2022-01-05